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Aristotle University of Thessaloniki
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Assessment
of neurotoxic and cardiotoxic action of pesticides and other chemical
compounds using in vitro physiological methods based on mammalian and
invertebrates nerve and cardiac tissue
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Name:
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THEOPHILIDIS , George ( Professor)
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Position:
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Director of Laboratory
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Name of
Organisation:
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Aristotle University of
Thessaloniki
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URL:
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http://www.auth.gr/biogengr/html/en/member.php@cat2_id=5.htm
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E-mail:
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Contact
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Telephone:
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+30-2310-998261
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Fax number:
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+30-2310-998269
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Collaboration
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Type: Project Proposal
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Title: Assessment of neurotoxic and cardiotoxic action
of pesticides and other chemical compounds using in vitro physiological
methods based on mammalian and invertebrates nerve and cardiac tissue
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Participation:
Type A
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Type
Details: NEUROTOXICITY- in
vitro of various chemicals will be assessed using the isolated in a
special recording chamber sciatic nerve of the frog or rat.
Electrophysiological records of the evoked compound action potential
will be recorded for more than 3 days (1 day for rat). The nerve will
be exposed to the chemical under investigation while the
vitality-curves of the nerves will be plotted using proper computer
software and hardware. The dose-response curves will be plotted (see
http://www.auth.gr/biogengr/html/en/member.php@cat2_id=5.htm
NEUROTOXICITY- in vitro
of various insecticides (nicotinic, organophosphate) on the central
nervous system of honeybee.
NEUROTOXICITY-IN VIVO
of various compounds in an anesthetized rat while respiratory rhythm
and cardiac activity (ECG) will be monitored. The drugs will be
injected through the carotid. The animal will be observed for days
after the operation.
CARDIOTOXICITY -IN
VITRO: action of pesticides and other chemical compounds will be
investigated using the isolated in saline auricle of the heart of the
rat, fish, amphibian(frog) and insects(honey bees, Drosophila, beetle).
Electophysiological measurements of the heart electromechanical
properties will be measured in the presence of normal saline and in the
presence of the chemical compound diluted in the saline-carrier. The
dose-response curves will be plotted (for details of the method and
related publications see
http://www.auth.gr/biogengr/html/en/member.php@cat2_id=5.htm
CARDIOTOXICITY -IN
VIVO: of various compounds using an anesthetized rat while cardiac
activity, ECGs, will be monitored. The drugs will be injected through
the carotid. The animal will be observed for days after the operation.
Using the above methods
a numbers of publications, over 20 papers, have been publishes (average
impact factor 2.3)
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Programme: COST , EUREKA
, ASIA-ITC
, TECHNOLOGY
PLATFORMS , FP7 , FP7-EURATOM
, FP7-JRC
, FP7-IDEAS
, FP7-COOPERATION
, FP7-PEOPLE
, FP7-HEALTH
, FP7-ICT
, FP7-ENVIRONMENT
, FP7-INCO
, FP7-COORDINATION
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Instruments:
NoE Networks of
Excellence,CSA-CA Coordination (or networking) actions,169 Joint
implementation of well identified national research programmes,BSG-SME
Research for SMEs,BSG-SME-AG Research for SME
associations/groupings,CP-FP Small or medium-scale focused research
project,CP-IP Large-scale integrating project,CP-TP Collaborative
Project targeted to a special group (such as SMEs),CSA-ERA-Plus ERA-NET
Plus,Infrastr-171 Construction of new infrastructures ,MC-ERG European
Re-integration Grants (ERG),MC-IAPP Industry-Academia Partnerships and
Pathways (IAPP),MC-IOF International Outgoing Fellowships (IOF)
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Research
interest:
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Expiry
Date: 2009-05-27
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Workprogramme
area(s)/key action(s):
(FP7-HEALTH
HEALTH-2007-2) Translating research for human health
(FP7-PEOPLE PEOPLE-3)
Industry-academia partnerships and pathways
(FP7-PEOPLE
PEOPLE-2007-2-1.IEF) Marie Curie Action: "Intra-European
Fellowships for Career Development"
(FP7-HEALTH
HEALTH-2007-2.4.3) Diabetes and obesity
(FP7-PEOPLE
PEOPLE-2007-5-2.NIGHT) Marie Curie Action: "Researchers' Night
2008"
(FP7-INCO
INCO-2007-3.2) ERA-NET PLUS projects "International Cooperation"
(FP7-ENVIRONMENT
ENV-1.2.1) Health effects of exposure to environmental stressors
(FP7-HEALTH
HEALTH-2007-2.2) Research on the brain and related diseases, human
development and ageing
(FP7-PEOPLE
PEOPLE-2007-4-3.IRG) Marie Curie Action: "International
Reintegration Grants"
(FP7-PEOPLE
PEOPLE-2007-4-2.IIF) Marie Curie Action: "International Incoming
Fellowships"
(FP7-INCO
INCO-2007-1.3) Eastern European and Central Asia Region
(FP7-ENVIRONMENT
ENV-3.3.1) Risk assessment of chemicals and alternative strategies for
testing
(FP7-ENVIRONMENT
ENV-3.3.3) Environmental Technologies Verification and Testing
(FP7-INCO
INCO-2007-3.1) ERA-NET projects "International Cooperation"
(FP7-ENVIRONMENT
ENV-1.2.3) Delivery of methods and decision support tools for risk
analysis and policy development
(FP7-ENVIRONMENT ENV-3)
Environmental technologies
(FP7-HEALTH HEALTH-1)
Biotechnology, generic tools and medical technologies for human health
(FP7-PEOPLE
PEOPLE-2007-2-3.COFUND) Marie Curie Action: "Co-funding of
Regional, National and International Programmes "
(FP7-ENVIRONMENT
ENV-1.2.2) Integrated approaches for environment and health risk
assessment
(FP7-PEOPLE
PEOPLE-2007-1-1.ITN) Marie Curie Action: "Networks for Initial
Training"
(FP7-PEOPLE PEOPLE-2007-5-1.NIGHT)
Marie Curie Action: "Researchers' Night 2007"
(FP7-ENVIRONMENT
ENV-1.1) Pressures on environment and climate
(FP7-HEALTH
HEALTH-2007-2.1.2) Systems biology
(FP7-ENVIRONMENT
ENV-3.3) Technology assessment, verification and testing
(FP7-HEALTH
HEALTH-2007-2.2.1) Brain and brain-related diseases
(FP7-ENVIRONMENT
ENV-1.2) Environment and Health
(FP7-PEOPLE
PEOPLE-2007-5-2.AWARDS) Marie Curie Action: "Marie Curie Awards
2007"
(FP7-HEALTH
HEALTH-2007-2.3.1) Anti-microbial drug resistance including fungal
pathogens
(FP7-ENVIRONMENT ENV-1)
Climate change, pollution, and risks
(FP7-PEOPLE
PEOPLE-2007-5-3.ERA-MORE) ERA-MORE
(FP7-INCO
INCO-2007-1.2) Mediterranean Partner countries Region
(FP7-HEALTH
HEALTH-2007-1.2) Detection, diagnosis and monitoring
(FP7-ENVIRONMENT
ENV-3.1) Environmental technologies for observation, simulation,
prevention, mitigation, adaptation, remediation and restoration of the
natural and man-made environment
(FP7-ENVIRONMENT ENV-2.1.4)
Biodiversity
(FP7-PEOPLE PEOPLE-2007-3-1.IAPP)
Marie Curie Action: "Industry-Academia Partnerships and
Pathways"
(FP7-PEOPLE
PEOPLE-2007-2-2.ERG) Marie Curie Action: "European Reintegration
Grants"
(FP7-ENVIRONMENT
ENV-1.3.3) Risk assessment and management
(FP7-PEOPLE
PEOPLE-2007-4-1.IOF) Marie Curie Action: "International Outgoing
Fellowships for Career Development"
(FP7-ICT ICT-2007.9.2)
International cooperation (ICT-2007.9.2)
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Target Partner
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Expertise:
In vitro testing, pharmaceutical
companies producing pesticides (insecticides, fungicides, herbicides,
anticancer drugs, and require the assessment of their neurotoxicity and
cardiotoxicity. Tissue culture.
Also Universities or
SMEs involved in EU projects related to Sustainable apiculture and
honey production, FP 7
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Country: Österreich, Belgique-België,
Schweiz/Suisse/Svizzera, Ceska Republika, Deutschland, Danmark, Eesti,
España, Suomi/Finland, France, United Kingdom, Hellas, Magyarorszag,
Ísland, Italia, Lietuva, Luxembourg (Grand-Duché), Latvija, Malta,
Nederland, Polska, Portugal, Sverige, Slovenija, Slovenska Republika
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Name:
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Aristotle University of
Thessaloniki
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Department:
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Zoology
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Address:
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Aristotle University
University Campus
54124
Thessaloniki
HELLAS
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Type:
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Consultancy, Research,
Education, Industry
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Number of
Employees:
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> 500
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Details:
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SIC Codes:
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Agricultural biotechnology ,
Agriculture , Life Sciences , Measurement Methods , Medicine, Health ,
Scientific Research
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Keywords:
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environment
pesticides
chemicals
neurotoxicit
vitro
INSECTICIDES
mammalians
honeybee
CARDIOTOXICITY
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Partners
already acquired:
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Record
control number: 80153
Quality validation date: 2008-05-30
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CORDIS RTD-Partners
/ © European Communities.
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